Synthetic Zwitterionic <i>Streptococcus pneumoniae</i> Type 1 Oligosaccharides Carrying Labile <i>O</i> ‐Acetyl Esters

Microarrays of synthetic heparin oligosaccharides.

We present the first preparation of microarrays containing synthetic heparin oligosaccharides in order to elucidate the heparin-protein interactions involved in a variety of biological processes. For this purpose, we have developed a novel linker strategy that is compatible with the protecting-group manipulations required for the synthesis of the highly sulfated oligosaccharides and can also be...

Atmospheric pressure MALDI Fourier transform mass spectrometry of labile oligosaccharides.

An atmospheric pressure matrix-assisted laser desorption/ionization (AP MALDI) source coupled to Fourier transform ion cyclotron resonance mass spectrometry (FT ICR MS) under UV laser and solid matrix conditions has been demonstrated to analyze a variety of labile oligosaccharides including O-linked and N-linked complex glycans released from glycoproteins. Spectra were acquired by both AP MALDI...

Synthesis and oral absorption of hetacillin and hetamoxicillin labile esters.

Zwitterionic 5-(1-piperidiniomethyl)-1H-tetrazolide.

The title compound, C(7)H(13)N(5), a tetrazole analogue of betaines, exists as a zwitterion, with the H atom of the tetrazole ring being transferred to the piperidine ring N atom. The tetrazole ring symmetry is close to C(2v), which suggests strong charge delocalization in the N-C-N fragment of the ring. There are classical hydrogen bonds in the structure which are responsible for the formation...

Zwitterionic (4-benzyl­piperidinium-1-yl­meth­yl)phospho­nate

The title compound, C(13)H(20)NO(3)P, exists as a zwitterion: the phospho-nic acid group has transferred its H atom to the amino group. The piperidine ring adopts a chair conformation. Mol-ecules are linked via hydrogen bonding to form a linear chain.